Elevated c-Src and c-Yes expression in malignant skin cancers

Elevated c-Src and c-Yes expression in malignant skin cancers

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Abstracts Background Src family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis.Among the SFKs, c-Src and c-Yes are particularly over-expressed or hyper-activated in many human epithelial cancers.However, only a few studies have attempted to define the expression and role of c-Src and c-Yes in cutaneous carcinomas.Objectives To investigate the expression of c-Src and c-Yes in cutaneous carcinomas to include malignant melanoma (MM), squamous cell carcinoma (SCC) Parts Washer and basal cell carcinoma (BCC).

Methods We examined 6 normal skin tissues and 18 malignant skin tumor tissues using western blotting for the expression of c-Src and SALT HAIR SPRAY c-Yes.In another set, 16 specimens of MM, 16 SCCs and 16 BCCs were analyzed for the expression of c-Src and c-Yes using immunohistochemical staining.Results Western blotting showed that c-Src was expressed in all malignant skin tumors, but not in normal skin, while c-Yes was expressed in MM and SCC, but not in BCC and normal skin.Immunohistochemical staining results of c-Src and c-Yes in MM, SCC, and BCC mirrored those of the western blot analysis.

Conclusions c-Src, rather than c-Yes, plays a key role in the proliferation and progression of malignant skin cancers.